License to kill: IFN-λ regulates antifungal activity of neutrophils.
نویسندگان
چکیده
Interferon-λ mediates antifungal immunity by stimulating neutrophils to generate reactive oxygen species.
منابع مشابه
Type III interferon is a critical regulator of innate antifungal immunity.
Type III interferons (IFN-λs) are the most recently found members of the IFN cytokine family and engage IFNLR1 and IL10R2 receptor subunits to activate innate responses against viruses. We have identified IFN-λs as critical instructors of antifungal neutrophil responses. Using Aspergillus fumigatus (Af) as a model to study antifungal immune responses, we found that depletion of CCR2+ monocytes ...
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ورودعنوان ژورنال:
- Science immunology
دوره 2 17 شماره
صفحات -
تاریخ انتشار 2017